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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Replication in Eukaryotes01:29

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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Replication in Eukaryotes02:31

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Updated: Dec 13, 2025

Detection of Modified Forms of Cytosine Using Sensitive Immunohistochemistry
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Epigenetic Clock: DNA Methylation in Aging.

Shuang Jiang1, Yuchen Guo1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Stem Cells International
|July 30, 2020
PubMed
Summary
This summary is machine-generated.

DNA methylation patterns are key regulators of aging and biological age. Understanding these epigenetic modifications may lead to life extension and treatments for age-related diseases.

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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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Immunohistochemical Detection of 5-Methylcytosine and 5-Hydroxymethylcytosine in Developing and Postmitotic Mouse Retina
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Related Experiment Videos

Last Updated: Dec 13, 2025

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Area of Science:

  • Epigenetics and aging research.
  • Molecular mechanisms of aging.

Background:

  • Aging is a natural process characterized by declining organ function and increased disease risk.
  • Epigenetic modifications, particularly DNA methylation, play a crucial role in regulating aging.
  • Changes in DNA methylation patterns correlate with biological age and disease prognosis.

Purpose of the Study:

  • To review recent findings on the link between DNA methylation patterns and aging.
  • To introduce mechanisms of DNA methylation regulators in aging and related diseases.

Main Methods:

  • Literature review of recent studies on DNA methylation and aging.
  • Analysis of epigenetic modifications and their regulatory roles.

Main Results:

  • DNA methylation levels fluctuate with age and can predict biological age.
  • Specific DNA methylation regulators influence aging processes and associated diseases.

Conclusions:

  • DNA methylation is a critical factor in aging.
  • Further research into DNA methylation mechanisms could yield anti-aging interventions and therapies for age-related conditions, potentially extending human lifespan.