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Along for the Ride: Intrahepatic Cholangiocarcinoma with Concomitant LECT2 Amyloidosis
Phoenix D Bell1, Aaron R Huber1, Tom C DeRoche2
1University of Rochester Medical Center, Rochester, NY, USA.
Case Reports in Pathology
|July 30, 2020
Summary
This case study details a rare instance of intrahepatic cholangiocarcinoma co-occurring with leukocyte chemotactic factor-2 (LECT2) amyloidosis. The findings highlight a unique association between these two distinct pathologies in a liver mass.
Area of Science:
- Gastroenterology and Hepatology
- Oncology
- Pathology
Background:
- Intrahepatic cholangiocarcinoma (ICC) is a primary liver malignancy with diverse etiologies.
- Amyloidosis is a group of disorders characterized by extracellular deposition of misfolded proteins.
Observation:
- A 69-year-old male with type II diabetes presented with abdominal pain and a liver mass.
- Biopsy revealed atypical glands positive for CK7, indicative of ICC.
- Congo red staining and polarized light microscopy showed amyloid deposits, confirmed as LECT2 type by mass spectrometry.
Findings:
- The liver mass demonstrated features of intrahepatic cholangiocarcinoma.
- Associated amyloidosis was identified as the LECT2 subtype.
- This represents the first reported case of ICC associated with LECT2 amyloidosis.
Implications:
- This case expands the known associations of LECT2 amyloidosis.
- It suggests a potential link between LECT2 amyloidosis and the development of intrahepatic cholangiocarcinoma.
- Further research is warranted to explore the pathogenetic mechanisms underlying this association.
