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Updated: Dec 13, 2025

Colon Ascendens Stent Peritonitis CASP - a Standardized Model for Polymicrobial Abdominal Sepsis
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Current Status and Prospects of Spontaneous Peritonitis in Patients with Cirrhosis

Yong-Tao Li1, Jian-Rong Huang1, Mei-Lian Peng2

  • 1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003 Zhejiang Province, China.

Biomed Research International
|July 30, 2020
PubMed

Insights

Spontaneous bacterial peritonitis (SBP) is a common complication in cirrhotic ascites. Early diagnosis and treatment are crucial for managing SBP, especially when rare pathogens are suspected.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Microbiology

Background:

  • Spontaneous bacterial peritonitis (SBP) is a frequent complication of cirrhotic ascites.
  • SBP exacerbates the patient's clinical condition.
  • Gram-negative bacilli are the primary cause, with gram-positive cocci implicated to a lesser extent.

Purpose of the Study:

  • To highlight the importance of early diagnosis and timely treatment of SBP.
  • To emphasize the role of bacterial translocation in SBP pathogenesis.
  • To suggest exploring rare pathogens when standard treatment is ineffective.

Main Methods:

  • Review of existing literature on SBP pathogenesis and treatment.
  • Analysis of etiological factors and geographical variations in bacterial strains.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • Hospital-acquired infections often involve drug-resistant bacteria.
  • Pathogen distribution varies geographically, leading to different bacterial strains in hospitals.
  • Intestinal changes and compromised immunity in cirrhosis patients contribute to bacterial translocation.

Conclusions:

  • Early diagnosis and prompt treatment are vital for effective SBP management.
  • Consideration of rare pathogens is necessary if initial treatments fail.
  • Understanding bacterial translocation mechanisms is key to SBP prevention and treatment.

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