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Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
Published on: April 10, 2019
Advances in Exosomes Derived from Different Cell Sources and Cardiovascular Diseases
Bo Liang1, Xin He1, Yu-Xiu Zhao2
1Nanjing University of Chinese Medicine, Nanjing, China.
Insights
Exosomes are key in cardiovascular health, acting as biomarkers and therapeutic agents. This review details their diagnostic and prognostic applications in cardiovascular diseases.
Area of Science:
- Cardiovascular Biology
- Cellular Communication
- Biomarker Discovery
Background:
- Exosomes facilitate intercellular communication via blood circulation, regulating intracellular signals.
- Exosomes are integral to cardiovascular pathophysiology, with diverse sources and cargos.
- Their roles extend beyond biomarkers to diagnosis, treatment, and prevention of cardiovascular diseases.
Purpose of the Study:
- To review current applications of exosomes in cardiovascular disease prognosis and diagnosis.
- To highlight the significance of exosomes derived from various sources.
Main Methods:
- Literature review of up-to-date research on exosome applications.
- Analysis of exosome roles in cardiovascular disease prognosis and diagnosis.
Main Results:
- Exosomes from different sources exhibit distinct mechanisms and cargos.
- Exosomes show potential as diagnostic and prognostic tools in cardiovascular diseases.
Conclusions:
- Exosomes are crucial for understanding and managing cardiovascular diseases.
- Further research into exosome applications can advance cardiovascular medicine.
Abstract:
Exosomes can reach distant tissues through blood circulation to communicate directly with target cells and rapidly regulate intracellular signals. Exosomes play an important role in cardiovascular pathophysiology. Different exosomes derived from different sources, and their cargos have different mechanisms of action. In addition to being biomarkers, exosomes also have a certain significance in the diagnosis, treatment, and even prevention of cardiovascular diseases. Here, we provide a review of the up-to-date applications of exosomes, derived from various sources, in the prognosis and diagnosis of cardiovascular diseases.
