Antimicrobial Resistance in Typhoidal Salmonella: Around the World in 3 Days

Area of Science:

• * Infectious Diseases
• * Microbiology
• * Global Health

Background:

• * Increasing antimicrobial resistance in typhoidal Salmonella poses a significant threat to public health.
• * The limited pipeline of novel antimicrobials exacerbates the risk of uncontrolled enteric fever.
• * Enteric fever, caused by typhoidal Salmonella, leads to widespread morbidity and mortality globally.

Purpose of the Study:

• * To summarize recent findings on the phenotypic and genotypic characteristics of antimicrobial resistance in typhoidal Salmonella.
• * To provide a global overview of antimicrobial resistance trends in typhoidal Salmonella, based on international research.
• * To highlight the challenges and future directions in combating antimicrobial resistance in enteric fever.

Main Methods:

• * Review of at least 50 abstracts presented at a global conference on antimicrobial resistance (March 26-28, 2019, Hanoi, Vietnam).
• * Analysis of data covering phenotypic and genotypic characteristics of antimicrobial resistance in typhoidal Salmonella.
• * Inclusion of data from at least 24 countries across 5 continents.

Main Results:

• * A significant portion of presented research focused on antimicrobial resistance in typhoidal Salmonella.
• * Data from numerous countries indicated widespread resistance patterns.
• * Findings covered diverse phenotypic and genotypic aspects of resistance.

Conclusions:

• * Antimicrobial resistance in typhoidal Salmonella is a critical global concern requiring immediate attention.
• * A comprehensive understanding of resistance mechanisms is essential for developing effective control strategies.
• * International collaboration and continued research are vital to address the threat of enteric fever.