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Bab2 Functions as an Ecdysone-Responsive Transcriptional Repressor during Drosophila Development

Jianli Duan1, Yunpo Zhao2, Haichao Li3

  • 1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden; CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.

Cell Reports
|July 30, 2020
PubMed
Summary

Bric-à-brac 2 (Bab2) acts as a key repressor, controlling gene timing during Drosophila metamorphosis. It terminates salivary gland secretion gene expression, ensuring proper development in response to ecdysone steroid pulses.

Keywords:
Bab2BroadDrosophilaEcR/USPSgs genesecdysoneglue genessalivary glandsteroid hormonetranscriptional regulation

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