Related Experiment Video
Updated: Dec 13, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
Understanding and Preventing Placenta-Mediated Pregnancy Complications
Leslie Skeith1, Marc Blondon2, Fionnuala Ní Áinle3
1Division of Hematology and Hematological Malignancies, Department of Medicine, University of Calgary, Calgary, Canada.
This review explores how blood clotting (hemostasis) relates to placenta-mediated pregnancy complications like preeclampsia. It examines antithrombotic treatments, highlighting mixed results and future research directions for improved maternal health.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Reproductive Medicine
Background:
- Placenta-mediated pregnancy complications, including preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss, represent significant clinical challenges.
- The pathophysiology is intricate, with potential links to prothrombotic disorders like antiphospholipid syndrome, an area requiring further elucidation.
Related Concept Videos
Mitral Valve Prolapse III: Nursing Management
Teratogenicity
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

