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Melatonin as a Radio-Sensitizer in Cancer.

Carolina Alonso-González¹, Alicia González¹, Javier Menéndez-Menéndez¹

¹Department of Physiology and Pharmacology, School of Medicine, University of Cantabria and Instituto de Investigación Sanitaria Valdecilla (IDIVAL), 39011 Santander, Spain.

|July 31, 2020

Summary

Melatonin, a natural hormone, enhances radiotherapy effectiveness and protects normal cells from damage. This makes melatonin a promising adjuvant therapy for cancer treatment.

Keywords:

cancer cells melatonin radiosensitization radiotherapy

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Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

Area of Science:

Oncology
Endocrinology
Radiation Biology

Background:

Radiotherapy is a primary cancer treatment.
Adjuvant therapies aim to improve tumor response and reduce side effects.
Radiosensitizers enhance radiation's effect on tumors with minimal harm to normal tissues.

Purpose of the Study:

To evaluate melatonin as a radiosensitizer and protective agent in cancer therapy.
To explore the mechanisms by which melatonin influences radiotherapy outcomes.

Main Methods:

Review of studies investigating melatonin's effects in conjunction with radiotherapy.
Analysis of preclinical and clinical data on melatonin's role in cancer treatment.

Main Results:

Melatonin enhances radiotherapy's therapeutic effects on tumor cells.
Melatonin demonstrates protective effects on normal tissues against radiation-induced side effects.
Multiple mechanisms, including oxidative stress modulation, DNA repair interference, and apoptosis induction, contribute to melatonin's radiosensitizing properties.

Conclusions:

Melatonin shows significant potential as an effective adjuvant therapy when combined with radiotherapy.
Further clinical trials are warranted to fully establish melatonin's therapeutic utility in human cancer patients.