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Updated: Dec 13, 2025

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
Published on: May 30, 2013
The Potential of Immune Modulation in Therapeutic HIV-1 Vaccination
Nabila Seddiki1,2,3,4, Florence Picard1,3, Léa Dupaty1,3
1Inserm, U955, Equipe 16, 94000 Créteil, France.
Abstract:
We discuss here some of the key immunological elements that are at the crossroads and need to be combined to develop a potent therapeutic HIV-1 vaccine. Therapeutic vaccines have been commonly used to enhance and/or recall pre-existing HIV-1-specific cell-mediated immune responses aiming to suppress virus replication. The current success of immune checkpoint blockers in cancer therapy renders them very attractive to use in HIV-1 infected individuals with the objective to preserve the function of HIV-1-specific T cells from exhaustion and presumably target the persistent cellular reservoir. The major latest advances in our understanding of the mechanisms responsible for virus reactivation during therapy-suppressed individuals provide the scientific basis for future combinatorial therapeutic vaccine development.
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