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Updated: Dec 13, 2025

Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Genetic Susceptibility of the Host in Virus-Induced Diabetes
Keiichiro Mine1,2, Yasunobu Yoshikai2, Hirokazu Takahashi1,3
1Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, 5-1-1, Nabeshima, Saga 849-8501, Japan.
Abstract:
Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.
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