Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Reorganization of Corticostriatal Connectivity Across the Degree of Nigrostriatal Degeneration in Parkinson Disease.

Neurology·2026
Same author

Neuroprotective Effects of Transplanted Induced Pluripotent Stem Cell-Derived Neural Precursors in Huntington's Disease Models.

International journal of stem cells·2026
Same author

Interplay of age-sensitive cortical vulnerability and dopaminergic degeneration in clinical manifestations of Parkinson's disease.

Neurobiology of aging·2026
Same author

Clinical-Grade Human Induced Pluripotent Stem Cell-Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid-Lesioned Rat Model of Huntington's Disease.

Cell proliferation·2026
Same author

Efficacy and Safety of Taltirelin Hydrate in Patients With Ataxia Due to Spinocerebellar Degeneration.

Journal of movement disorders·2026
Same author

Plasma p-tau217 predicts PET-based pathological staging for precision Alzheimer disease assessment.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Related Experiment Video

Updated: Dec 13, 2025

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
11:52

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Published on: August 26, 2021

2.6K

Modeling of Frontotemporal Dementia Using iPSC Technology.

Minchul Kim1, Hee Jin Kim2,3,4,5,6, Wonyoung Koh1

  • 1Department of Biomedical Science, CHA Stem Cell Institute, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 13488, Korea.

International Journal of Molecular Sciences
|July 31, 2020
PubMed
Summary

Frontotemporal dementia (FTD) patient neurons show increased cell death markers and abnormal protein expression, suggesting induced pluripotent stem cells can model FTD neurodegeneration for drug discovery.

Keywords:
cell deathdisease modelingdrug screeningfrontotemporal dementia (FTD)induced pluripotent stem cells (iPSC)staurosporine (STS)

More Related Videos

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells
10:18

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells

Published on: October 10, 2015

12.9K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.3K

Related Experiment Videos

Last Updated: Dec 13, 2025

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons
11:52

Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and Neurons

Published on: August 26, 2021

2.6K
Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells
10:18

Three-dimensional Quantification of Dendritic Spines from Pyramidal Neurons Derived from Human Induced Pluripotent Stem Cells

Published on: October 10, 2015

12.9K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.3K

Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Genetics

Background:

  • Frontotemporal dementia (FTD) involves progressive degeneration of brain lobes.
  • Behavioral variant FTD (bvFTD) is the most common subtype, with known pathological subtypes including FTD-tau, TDP-43, and FUS.
  • The underlying pathological mechanisms of bvFTD remain largely unknown.

Purpose of the Study:

  • To investigate the expression of pathological markers (p-Tau, TDP-43, FUS) in induced pluripotent stem cell-derived neurons (iPSNs) from bvFTD patients.
  • To examine cellular responses to stress, focusing on cell death pathways.
  • To assess the utility of iPSC technology in modeling bvFTD phenotypes.

Main Methods:

  • Generated iPSNs from two sporadic bvFTD patients and one control subject.
  • Utilized an FTD patient-derived iPSC line with a MAPT P301L mutation as a positive control for p-Tau.
  • Induced cellular stress using staurosporine (STS) to study cell death pathways.

Main Results:

  • bvFTD-iPSNs exhibited significantly increased active caspase-3 expression compared to controls under STS treatment.
  • Elevated levels of cell-death-related proteins (Bax/Bcl-2, cytochrome C) were observed in bvFTD-iPSNs.
  • Abnormal expression patterns of TDP-43 and FUS were detected in bvFTD-iPSNs.

Conclusions:

  • iPSC technology can effectively demonstrate neurodegenerative phenotypes in bvFTD.
  • This approach holds potential for studying FTD pathological mechanisms.
  • iPSC-derived neurons may facilitate future drug screening for FTD and related disorders.