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Updated: Dec 13, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

Smart Supra- and Macro-Molecular Tools for Biomedical Applications.

Mariana Pinteala¹, Marc J M Abadie^1,2, Radu D Rusu¹

¹"Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy, Grigore Ghica Voda Alley, 41A, 700487 Iasi, Romania.

Materials (Basel, Switzerland)

|July 31, 2020

Summary

Smart polymeric materials respond to biological triggers for advanced biomedical uses. This review covers responsive systems for drug delivery, gene therapy, and medical imaging.

Keywords:

biomedical applications bionanoconjugates controlled drug delivery gene therapy hydrogels non-viral vectors pH-responsive polymers smart polymers temperature-sensitive polymers

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Area of Science:

Biomaterials Science
Polymer Chemistry
Biomedical Engineering

Background:

Stimuli-responsive "smart" polymers mimic biological systems by reacting to environmental cues.
These materials undergo changes in properties like shape, solubility, and structure in response to stimuli.
Key triggers include pH and temperature, enabling tailored material behavior.

Purpose of the Study:

To review recent advancements in stimuli-sensitive molecular tools for biomedical applications.
To detail the design and mechanisms of smart synthetic instruments for creating responsive architectures.
To explore diverse applications of these smart materials in medicine.

Main Methods:

Review of literature on stimuli-responsive polymers and their applications.
Analysis of design principles for creating materials with specific environmental responses.
Categorization of applications into drug delivery, gene delivery, nanoconjugates, and imaging.

Main Results:

Exploration of temperature- and pH-responsive systems for controlled drug delivery.
Discussion of glycodynameric hydrogels for enhanced drug delivery capabilities.
Overview of polymeric non-viral vectors for efficient gene delivery.
Examination of metallic nanoconjugates for targeted biomedical applications.
Presentation of smart organic tools for advanced biomedical imaging.

Conclusions:

Stimuli-responsive polymers offer versatile platforms for sophisticated biomedical applications.
Tailored material design allows for precise control over drug release, gene transfection, and imaging.
Continued development in this field promises significant advancements in diagnostics and therapeutics.