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Prognostic value of heart failure echocardiography index in HF patients with preserved, mid-ranged and reduced

Jian-Shu Chen1, Ying Pei1, Cai-E Li1

  • 1Lanzhou University Second College of Clinical Medicine, Number 199 Donggang West Road, Chengguan District, Lanzhou, 730030, China.

BMC Cardiovascular Disorders
|July 31, 2020
PubMed

Insights

The heart failure echocardiography index (HFEI) effectively assesses cardiac function and predicts prognosis across heart failure types. This echocardiographic measure, alongside NT-proBNP, identifies patients at higher risk for adverse events.

Area of Science:

  • Cardiology
  • Echocardiography
  • Heart Failure Research

Background:

  • Heart failure (HF) encompasses diverse subtypes: HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF).
  • Accurate assessment of cardiac function and prognosis is crucial for managing these distinct HF populations.
  • Existing biomarkers and imaging techniques may not fully capture the complexity of cardiac dysfunction across all HF types.

Purpose of the Study:

  • To evaluate the clinical utility of the heart failure echocardiography index (HFEI) in assessing cardiac function.
  • To determine HFEI's ability to predict prognosis in patients with HFrEF, HFmrEF, and HFpEF.
  • To compare the predictive value of HFEI with the plasma level of N-terminal pro-B-type natriuretic peptide (NT-proBNP).

Main Methods:

  • A cohort of 489 consecutive HF patients was stratified into HFrEF, HFmrEF, and HFpEF groups.
  • Baseline characteristics and echocardiographic parameters, including HFEI, were compared across the three groups.
  • Multivariate logistic regression and receiver operating characteristic (ROC) curve analysis were employed to assess HFEI's correlation with adverse events and its prognostic value, alongside NT-proBNP.

Main Results:

  • HFEI was significantly higher in the HFrEF group compared to HFmrEF and HFpEF groups.
  • Both HFEI and plasma NT-proBNP levels were identified as independent risk factors for predicting short-term prognosis in HF patients.
  • An HFEI cutoff of 3.5 and NT-proBNP of 3000 pg/ml demonstrated moderate sensitivity and specificity in predicting poor prognosis in chronic heart failure (CHF).

Conclusions:

  • HFEI provides a comprehensive evaluation of overall cardiac function in patients with various types of heart failure.
  • HFEI shows potential as a valuable index for assessing the prognosis of heart failure patients.
  • Combined assessment with NT-proBNP may enhance prognostic accuracy in heart failure management.
Abstract

Keywords:
Heart failureHeart failure echocardiography index (HFEI)NT-proBNPPrognosis

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