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Outward transcutaneous chemical migration: implications for diagnostics and dosimetry
C C Peck1, D P Conner, B J Bolden
1Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Md.
Skin Pharmacology : the Official Journal of the Skin Pharmacology Society
|January 1, 1988
Summary
Researchers developed a new method to collect non-gaseous chemicals emitted from the skin. This technique allows for in vivo skin permeability studies and monitoring of chemical exposure without invasive procedures.
Area of Science:
- Dermatology
- Toxicology
- Analytical Chemistry
Background:
- Chemicals diffuse from the body to the skin surface via capillaries and epidermis.
- Previous studies focused only on gaseous chemical emissions from skin.
- Non-gaseous chemical migration through the skin was not well understood.
Purpose of the Study:
- To investigate the outward transcutaneous migration of non-gaseous chemicals.
- To develop a novel non-invasive method for collecting these emissions.
- To establish a technique for assessing skin permeability and chemical exposure.
Main Methods:
- Devised an occlusive transcutaneous chemical collection system.
- Utilized a tape-encased gelled saline plug with dispersed activated carbon.
- Collected emissions from rats, rhesus monkeys, and humans for nine different chemicals.
Main Results:
- Demonstrated outward transcutaneous chemical migration of non-gaseous substances.
- Collected data consistent with a general theory of transcutaneous chemical migration.
- Validated the technique across different species, including humans.
Conclusions:
- The developed system enables non-invasive, continuous transcutaneous sampling.
- This technique offers a new approach for in vivo skin permeability investigation.
- It may facilitate convenient diagnosis and monitoring of chemical exposure.