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Updated: Dec 13, 2025
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
Published on: July 28, 2010
A Model for Predicting DNA Mismatch Repair-deficient Colorectal Cancer
Kenichi Chikatani1, Noriyasu Chika2, Okihide Suzuki2
1Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan chikatan@saitama-med.ac.jp.
Background/Aim:
Identifying patients with DNA mismatch repair-deficient (dMMR) colorectal cancer (CRC) is vital to improve treatment and identify patients with Lynch syndrome (LS). We developed a prediction model for dMMR CRC using clinicopathologic features.
Patients And Methods:
We reviewed the medical records of 1,147 patients who underwent resection of stage I-IV CRC in whom universal screening for LS using immunohistochemistry for MMR proteins had performed. Univariate and multivariate logistic regression analyses were used to build a prediction model of dMMR CRC.
Results:
The prevalence of dMMR CRC was 5.2%. Age (≥75 years), tumor location (right-sided colon), main histologic features (poor differentiation), maximum tumor size (≥65 mm), and stage (I/II) were independent significant variables related to dMMR. We created a formula for predicting the likelihood of dMMR, and the probability ranged from 0.2% to 83%.
Conclusion:
dMMR CRC can be identified efficiently using clinicopathologic features obtained in daily clinical practice.
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