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The Contribution of MMP-9 Genotypes to Pterygium in Taiwan

Chong-Bin Tsai1, Ning-Yi Hsia2,3, Zhi-Hong Wang4

  • 1Department of Ophthalmology, Chia-Yi Christian Hospital, Chia-Yi, Taiwan, R.O.C.

Anticancer Research
|July 31, 2020
PubMed
Abstract

Insights

Genetic variations in matrix metalloproteinase-9 (MMP-9) rs3918242 do not significantly influence pterygium risk. This study found no association between MMP-9 genotypes and susceptibility to pterygium development.

Area of Science:

  • Genetics
  • Ophthalmology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs), particularly MMP-9, are implicated in pterygium pathogenesis.
  • Previous research focused on MMP-9 mRNA and protein levels, neglecting genomic contributions.
  • The role of specific MMP-9 gene variants in pterygium risk remains underexplored.

Purpose of the Study:

  • To investigate the association between matrix metalloproteinase-9 (MMP-9) genotypes and the risk of developing pterygium.
  • To determine if the MMP-9 rs3918242 polymorphism contributes to pterygium susceptibility.

Main Methods:

  • Genotyping of the MMP-9 rs3918242 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  • Study included 134 pterygium cases and 268 healthy controls.
  • Statistical analysis included odds ratios and allelic frequency comparisons.

Main Results:

  • No significant differences in genotype frequencies (CC, CT, TT) of MMP-9 rs3918242 were observed between pterygium cases and controls.
  • Adjusted odds ratios for CT and TT genotypes did not indicate an increased risk for pterygium.
  • Allelic frequency analysis revealed no significant disparities between the case and control groups.

Conclusions:

  • The studied genotypes at MMP-9 rs3918242 appear to play a minimal role in determining an individual's susceptibility to pterygium.
  • Further research may be needed to explore other genetic factors or environmental influences on pterygium development.
Keywords:
AgeMMP-9Taiwangendergenotypepolymorphismpterygium

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