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Association between inflammatory bowel disease and bullous pemphigoid: a population-based case-control study
Yi-Ju Chen1,2,3, Chao-Kuei Juan4,5, Yun-Ting Chang5,6
1Department of Dermatology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Blvd., Taichung, 407, Taiwan. yjchenmd@vghtc.gov.tw.
Scientific Reports
|July 31, 2020
Summary
This study found a significant link between ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), and bullous pemphigoid (BP). Patients with UC had a higher risk of developing BP, suggesting a connection between these conditions.
Area of Science:
- Dermatology
- Gastroenterology
- Epidemiology
Background:
- The co-occurrence of inflammatory bowel disease (IBD) and bullous pemphigoid (BP) is recognized.
- Large-scale investigations into the IBD-BP relationship are lacking.
Purpose of the Study:
- To investigate the association between IBD and BP using a nationwide population-based dataset.
- To identify potential risk factors for BP in relation to IBD.
Main Methods:
- A population-based case-control study utilizing Taiwan's National Health Insurance Research Database (1997-2013).
- 5,263 BP patients were compared with 21,052 matched controls.
- Logistic regression analysis was employed to determine predicting factors for BP.
Main Results:
- BP patients exhibited a higher prevalence of cardiovascular risk factors, autoimmune diseases, neurological comorbidities, and hematologic cancers.
- Inflammatory bowel disease (IBD) was diagnosed in 0.38% of BP patients versus 0.16% of controls (p < 0.001).
- Ulcerative colitis (UC), a subtype of IBD, showed a significant independent association with BP (adjusted OR 3.60, p < 0.001).
Conclusions:
- Ulcerative colitis is independently associated with an increased risk of developing bullous pemphigoid.
- Further research is warranted to elucidate the underlying mechanisms connecting UC and BP.
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