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Related Experiment Video

Updated: Dec 13, 2025

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

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Current concepts in tumour-derived organoids.

Ross J Porter^1,2, Graeme I Murray¹, Mairi H McLean³

¹School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Scotland, UK.

British Journal of Cancer

|July 31, 2020

Summary

Organoids, complex 3D tissue cultures, offer a near-physiological model for cancer research. These self-organizing structures accurately represent cancer hallmarks, advancing personalized cancer therapies.

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Last Updated: Dec 13, 2025

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Published on: May 26, 2023

Establishment and Culture of Patient-Derived Breast Organoids

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Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging

Generating and Imaging Mouse and Human Epithelial Organoids from Normal and Tumor Mammary Tissue Without Passaging

Published on: November 11, 2022

Area of Science:

Oncology
Biotechnology
Regenerative Medicine

Background:

Cancer is a complex disease characterized by heterogeneous cells within an evolving tumor microenvironment.
Despite improved survival rates, many preclinical cancer studies fail to translate to clinical applications due to modeling challenges.
Organoids represent a significant advancement in ex vivo cancer modeling.

Purpose of the Study:

To review the utility of organoids in cancer research.
To highlight how organoids are shaping the future of cancer studies and personalized therapies.
To discuss the potential of organoids as a near-physiological model for cancer.

Main Methods:

Organoids are derived from stem cells or progenitor cells, self-organizing into 3D structures.
Organoid models accurately recapitulate genetic, cellular, and pathophysiological hallmarks of cancer.
Co-culture and genetic manipulation techniques enhance organoid utility.

Main Results:

Organoids provide a more accurate representation of human cancer complexity compared to traditional models.
Organoid technology facilitates the study of tumor heterogeneity and microenvironment interactions.
Organoid platforms show promise for drug screening and the development of personalized cancer treatments.

Conclusions:

Organoids offer a powerful and versatile platform for advancing cancer research.
This technology is crucial for bridging the gap between preclinical findings and clinical outcomes.
Organoids are poised to revolutionize cancer study and the implementation of tailored therapeutic strategies.