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Updated: Dec 13, 2025

Novel Sequence Discovery by Subtractive Genomics
Published on: January 25, 2019
Draft genome sequence of Neonectria sp. DH2 isolated from Meconopsis grandis Prain in Tibet
Xiaojing Lin1,2, Hui Xu2, Lan Liu1,3
1School of Marine Sciences, Sun Yat-sen University, Guangzhou, 510006 China.
Abstract:
In the current study, we report the high-quality draft genome sequence of Neonectria sp. DH2, an endophytic fungus isolated from Meconopsis grandis Prain in Tibet. The whole genome is about 45.8 Mbp, with a GC content of 53%. A total of 14,163 genes are predicted to encode proteins, and 557 of them are considered as unique, as no matches are found in five gene databases. A neighbor-joining phylogenetic tree based on internal transcribed spacer (ITS) region sequences shows that Neonectria sp. DH2 was most closely related to Neonectria ramulariae. 47 biosynthetic gene clusters (BGC) were identified in Neonectria sp. DH2 genome, and only 5 BGCs shows significant similarities to previously reported BGCs. The presence of 42 unique BGCs in Neonectria sp. DH2 suggests that it has great potential to produce novel secondary metabolites.

