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Related Experiment Video

Updated: Dec 13, 2025

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Parathyroidectomy slows renal function decline in patients with primary hyperparathyroidism.

C-C Liang^1,2, H-C Yeh^1,2, Y-C Lo³

¹Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Journal of Endocrinological Investigation

|July 31, 2020

Summary

Parathyroidectomy slows kidney function decline in primary hyperparathyroidism patients. This surgery benefits kidney health, particularly in younger individuals without chronic kidney disease or hypertension.

Keywords:

Estimated glomerular filtrate rate Parathyroidectomy Primary hyperparathyroidism Renal function

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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation

Published on: March 14, 2017

Area of Science:

Nephrology
Endocrinology
Surgical Research

Background:

Primary hyperparathyroidism (PHP) negatively impacts health, causing kidney stones and osteoporosis.
The effect of parathyroidectomy on kidney function in PHP patients remains uncertain.

Purpose of the Study:

To investigate the impact of parathyroidectomy on kidney function in patients with primary hyperparathyroidism.
To assess changes in estimated glomerular filtration rate (eGFR) following parathyroidectomy.

Main Methods:

Retrospective study of 27 primary hyperparathyroidism patients undergoing parathyroidectomy (2003-2017).
Analysis of longitudinal eGFR changes using various metrics (e.g., annual decline rate, slope).
Linear mixed-effect models applied to determine the effect of surgery on kidney function.

Main Results:

Parathyroidectomy significantly slowed the rate of eGFR decline (from -2.73 to -1.67 mL/min/1.73 m²/year).
No significant changes observed in proteinuria or eGFR distribution post-surgery.
Greater benefits on kidney function were noted in patients younger than 65 and those without hypertension or chronic kidney disease.

Conclusions:

Parathyroidectomy demonstrates a beneficial effect by slowing renal function decline in primary hyperparathyroidism patients.
Findings suggest potential revision of surgical guidelines for primary hyperparathyroidism.
Further large-scale controlled studies are needed to validate these results due to the small sample size.