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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
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Antigens Involved in Adaptive Immunity01:26

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Autoimmunity in 2019.

Carlo Selmi1,2

  • 1Division of Rheumatology and Clinical Immunology, Humanitas Clinical and Research Center - IRCCS, via Manzoni 56, Rozzano, 20089, Milan, Italy. carlo.selmi@hunimed.eu.

Clinical Reviews in Allergy & Immunology
|July 31, 2020
PubMed
Summary
This summary is machine-generated.

Research shows that autoimmune disease publications are a growing part of immunology literature, nearing 20% in 2019. Common themes and new mechanisms drive therapeutic developments in conditions like lupus and rheumatoid arthritis.

Keywords:
AutoantibodyImmune toleranceInnate immunityInterleukinMass cytometryPersonalized medicineRNA sequencingSingle-cell RNA sequencing

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Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Medical Research Trends

Background:

  • Annual evaluations of PubMed data track the proportion of autoimmune disease publications within immunology.
  • Autoimmune disease research continues to grow, representing a significant and increasing portion of the scientific literature.

Purpose of the Study:

  • To evaluate the relative weight of autoimmune disease publications in the scientific literature.
  • To identify common themes, novel pathogenic mechanisms, and therapeutic avenues in autoimmune diseases.

Main Methods:

  • Yearly analysis of PubMed data.
  • Arbitrary selection and discussion of peer-reviewed articles from major immunology and autoimmune disease journals.
  • Review of research on systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriatic arthritis (PsA), and autoantibodies (autoAbs).

Main Results:

  • The proportion of immunology manuscripts related to autoimmunity approached 20% in 2019.
  • Common themes in autoimmune diseases continue to outweigh peculiarities.
  • New pathogenetic evidence (e.g., IL21, P2X7R in SLE) and advanced analytical tools (e.g., scRNA-seq, mass cytometry in RA) are emerging.
  • The therapeutic pipeline for autoimmune diseases is expanding, driven by basic science and high-throughput tools.

Conclusions:

  • A strong link between basic and clinical science is crucial for advancing autoimmune disease understanding and treatment.
  • Continued growth in research and therapeutic development highlights the dynamic nature of the autoimmune disease field.