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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Related Experiment Video

Updated: Dec 13, 2025

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Bone loss around implants-is it metallosis?

Thomas G Wilson1

  • 1Private practice, Dallas, TX, USA.

Journal of Periodontology
|July 31, 2020
PubMed
Summary

Oral biofilm is linked to dental implant failure. However, metallosis, caused by titanium particles and ions, also contributes to bone loss around implants, similar to joint prostheses.

Area of Science:

  • Dental implantology
  • Biomaterials science
  • Orthopedic surgery

Background:

  • Oral biofilm is a primary suspect in dental implant failure.
  • The role of biofilm in peri-implant bone loss is widely acknowledged.
  • Alternative etiologies for implant failure warrant investigation.

Purpose of the Study:

  • To discuss the dual etiologies of dental implant failure: oral biofilm and metallosis.
  • To present evidence supporting metallosis as a cause of bone loss around dental implants.
  • To compare the effects of metallosis in dental implants with metal-on-metal joint prostheses.

Main Methods:

  • Review of current scientific literature on dental implant failure.
  • Analysis of evidence linking oral biofilm to peri-implant bone loss.
Keywords:
foreign body responseimplant failuremetallosis

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  • Examination of research on metallosis and its effects on surrounding tissues.

    • Main Results:

    • Oral biofilm's role in initiating bone loss around dental implants is established.
    • Metallosis, resulting from titanium particle and ion release, is a significant factor in bone loss.
    • Similar biological responses are observed in failed metal-on-metal joint prostheses, supporting the metallosis hypothesis.

    Conclusions:

    • Dental implant failure may result from oral biofilm, metallosis, or a combination of both.
    • Metallosis, driven by titanium debris, presents a comparable mechanism to adverse reactions in metal-on-metal joint implants.
    • Further research is needed to differentiate and manage these distinct etiologies of implant failure.