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Epidiolex-induced skin rash.

Jaysingh Singh1, Marika-Foteni Antimisiaris1

  • 1The Ohio State University Wexner Medical Center, Neurology department, Columbus, Ohio, USA.

Epileptic Disorders : International Epilepsy Journal with Videotape
|July 31, 2020
PubMed
Summary

Epidiolex (cannabidiol) rarely causes rash, but this case shows a delayed skin reaction in a patient with epilepsy. Further review explores potential mechanisms for this side effect.

Keywords:
CBDEpidiolexEpidiolex® (cannabidiol)antiepilepticscannabinoiddrug interactionhypersensitivity reactionrashskin

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Area of Science:

  • Pharmacology
  • Neurology
  • Dermatology

Background:

  • Epidiolex (cannabidiol) is an FDA-approved prescription medication for specific epilepsy syndromes.
  • It is increasingly utilized for treatment-resistant epilepsy.
  • Skin rash is a rarely reported adverse event in clinical trials of Epidiolex.

Observation:

  • A case study of a 23-year-old female with medically refractory epilepsy is presented.
  • The patient developed a delayed-onset skin rash attributed to Epidiolex use.
  • This highlights a potential adverse dermatological reaction to cannabidiol.

Findings:

  • The report documents a specific instance of Epidiolex-related skin rash.
  • The rash manifested in a delayed fashion after initiating treatment.
  • The study includes a review of potential mechanisms underlying this side effect.

Implications:

  • This case expands the known side effect profile of Epidiolex.
  • It underscores the importance of monitoring for dermatological reactions in patients using cannabidiol.
  • Further research into the mechanism of Epidiolex-induced rash may inform clinical management.