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Updated: Dec 13, 2025

Fluorescence-Based Measurements of Phosphatidylserine/Phosphatidylinositol 4-Phosphate Exchange Between Membranes
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A complex genetic interaction implicates that phospholipid asymmetry and phosphate homeostasis regulate Golgi

Mamoru Miyasaka1,2, Tetsuo Mioka1, Takuma Kishimoto1

  • 1Division of Molecular Interaction, Institute for Genetic Medicine, Hokkaido University Graduate School of Life Science, Sapporo, Hokkaido, Japan.

Plos One
|July 31, 2020
PubMed
Summary

This study reveals that luminal phosphate concentration, not just phospholipid flippases, is crucial for maintaining Golgi membrane function and phospholipid asymmetry in yeast cells. Disruptions in phosphate transport impact membrane trafficking and cellular stress responses.

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