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[Experience with daptomycin in a tertiary pediatric hospital]

María T Rosanova1, Norma Sberna2, Claudia Sarkis1

  • 1Servicio de Control Epidemiológico e Infectología, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.

Revista Chilena De Infectologia : Organo Oficial De La Sociedad Chilena De Infectologia
|July 31, 2020
PubMed
Abstract

Insights

Daptomycin is a safe and effective treatment for children with serious infections, including those caused by MRSA. It offers an alternative when vancomycin fails or causes toxicity.

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Antimicrobial Therapy

Background:

  • Vancomycin is the standard for MRSA infections but has limitations.
  • Poor tissue penetration, renal toxicity, and monitoring needs prompt alternatives.
  • Daptomycin emerges as a potential alternative for pediatric infections.

Purpose of the Study:

  • To evaluate the safety and effectiveness of daptomycin in pediatric patients.
  • To assess daptomycin's role in treating infections resistant to conventional therapies.

Main Methods:

  • Retrospective analysis of children with microbiologically confirmed infections treated with daptomycin.
  • Inclusion criteria: documented infections treated with daptomycin.

Main Results:

  • Most common infections: endocarditis (32%), bacteremia (25%), sepsis (14%).
  • MRSA was the predominant pathogen (64%).
  • Daptomycin used due to treatment failure (61%) or vancomycin toxicity (39%). Favorable response in 79% of patients. Adverse events were infrequent.

Conclusions:

  • Daptomycin shows promising efficacy and a favorable safety profile in pediatric patients.
  • It serves as a viable option for complex pediatric infections, especially those involving MRSA.

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