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Multi-species Conserved Sequences

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale studies have provided new insights into the evolutionary relationship between organisms.
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Related Experiment Video

Updated: Dec 13, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

Persistent minimal sequences of SARS-CoV-2.

Diogo Pratas^1,2,3, Jorge M Silva^1,2

¹Institute of Electronics and Informatics Engineering of Aveiro, 3810-193 Aveiro, Portugal.

Bioinformatics (Oxford, England)

|July 31, 2020

Summary

This summary is machine-generated.

Researchers discovered novel pathogen-specific DNA/RNA sequences (PmRAWs) in SARS-CoV-2, including one on the Spike protein. This finding offers new avenues for diagnostics and therapeutics against COVID-19.

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Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

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Related Experiment Videos

Last Updated: Dec 13, 2025

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

Quantification and Whole Genome Characterization of SARS-CoV-2 RNA in Wastewater and Air Samples

Published on: June 30, 2023

Area of Science:

Genomics
Virology
Bioinformatics

Background:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with significant mortality.
The lack of effective therapies necessitates innovative diagnostic and therapeutic strategies.

Purpose of the Study:

To identify unique pathogen-specific DNA/RNA sequences within the SARS-CoV-2 genome.
To explore the potential of these sequences for diagnostic and therapeutic applications.

Main Methods:

Analysis of SARS-CoV-2 genomes to detect short persistent DNA/RNA sequences (PmRAWs) absent in the human genome.
Utilized protein structural prediction to localize identified PmRAWs.
Developed an improved alignment-free computational method for pathogen signature identification.

Main Results:

Identified conserved PmRAWs in SARS-CoV-2, with one located on the Spike glycoprotein, crucial for cell entry.
Localized a PmRAW on the Spike protein's surface, suggesting its utility as a diagnostic/therapeutic target.
Discovered a novel pattern of relative absent words (RAWs) with increasing GC content correlating with decreasing sequence length, observed in SARS-CoV-2 and Ebola virus.

Conclusions:

Novel pathogen-specific sequences (PmRAWs) have been identified in SARS-CoV-2.
A PmRAW on the Spike protein presents a potential target for developing diagnostics and therapeutics.
The study introduces an enhanced computational method for pathogen signature discovery and highlights a unique genomic pattern in viruses.