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Related Concept Videos

Brain Imaging01:14

Brain Imaging

548
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
548

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Related Experiment Video

Updated: Dec 13, 2025

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Brain microstructural changes and cognitive function in non-demented essential tremor patients: a diffusion tensor

Y Sengul1,2, H O Temur3, Z Corakcı4

  • 1Department of Neurology, Bezmialem Foundation University School of Medicine, Bezmialem Foundation University, Istanbul, Turkey.

The International Journal of Neuroscience
|July 31, 2020
PubMed
Summary
This summary is machine-generated.

Essential tremor (ET) involves cognitive impairment linked to widespread brain changes, not just the cerebello-thalamo-cortical pathway. Diffusion tensor imaging reveals microstructural alterations in grey and white matter correlating with cognitive deficits in ET patients.

Keywords:
Essential tremorcognitive impairmentdiffusion tensor imagingnon-motor symptom

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Area of Science:

  • Neuroimaging
  • Neuropsychology
  • Neurology

Background:

  • Essential tremor (ET) presents with both motor and non-motor symptoms, including cognitive impairment.
  • Cognitive deficits in ET are often attributed to the cerebello-thalamo-cortical pathway, but broader brain involvement is suspected.

Purpose of the Study:

  • To investigate brain microstructural changes in grey and white matter in non-demented ET patients using diffusion tensor imaging (DTI).
  • To correlate observed microstructural changes with cognitive function assessed through detailed neuropsychological testing.

Main Methods:

  • Thirty-five non-demented ET patients underwent comprehensive neuropsychological evaluation and brain MRI with DTI.
  • Region of interest (ROI)-based DTI analysis quantified microstructural changes (fractional anisotropy, average diffusion coefficient) in 32 brain areas.
  • Cognitive domains assessed included attention, visuospatial function, executive function, memory, and language.

Main Results:

  • Microstructural changes were identified in prefrontal cortical areas, limbic and paralimbic structures, basal ganglia, and various white matter tracts.
  • These changes significantly correlated with specific cognitive domains in ET patients.
  • Specific correlations were observed between alterations in areas like the substantia nigra and hippocampus and cognitive performance.

Conclusions:

  • Cognitive dysfunction in ET is associated with microstructural changes in a wide array of brain structures beyond the cerebello-thalamo-cortical pathway.
  • These findings highlight the complex neural networks underlying cognitive function in Essential Tremor.