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Parental cardiorespiratory conditions and offspring fracture: A population-based familial linkage study
Shuman Yang1, Lisa M Lix2, Lin Yan2
1Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.
Insights
Parental congestive heart failure and chronic obstructive pulmonary disease (COPD) increase offspring fracture risk. This study highlights the importance of family history in assessing major osteoporotic fracture (MOF) risk.
Area of Science:
- Cardiovascular Health
- Bone Health
- Genetics and Family History
Background:
- The influence of parental cardiovascular conditions on offspring fracture risk remains largely unexplored.
- Understanding familial predispositions is crucial for comprehensive fracture risk assessment.
Purpose of the Study:
- To investigate the association between parental cardiorespiratory conditions and the risk of major osteoporotic fractures (MOF) in offspring.
- To identify specific parental conditions that may confer an increased MOF risk to their children.
Main Methods:
- A population-based retrospective cohort study involving over 279,000 offspring aged 40 years and older.
- Ascertainment of parental cardiorespiratory conditions (e.g., congestive heart failure, COPD) from medical records.
- Tracking offspring for incident major osteoporotic fractures (MOF) over an average follow-up of 11.8 years.
Main Results:
- Parental congestive heart failure and chronic obstructive pulmonary disease (COPD) were independently associated with a significantly increased risk of offspring MOF.
- Hazard ratios for MOF were 1.13 for parental congestive heart failure and 1.12 for parental COPD.
- No significant association was found between parental hypertension, ischemic heart disease, myocardial infarction, or cerebrovascular disease and offspring MOF risk.
Conclusions:
- Parental congestive heart failure and COPD are identified as independent risk factors for major osteoporotic fractures in offspring.
- These findings underscore the importance of considering parental cardiovascular and respiratory health when evaluating an individual's fracture risk profile.
Background:
The role of parental cardiorespiratory conditions on fracture risk is unclear. We examined the associations between parental cardiorespiratory conditions and offspring fracture risk.
Methods:
In this population-based retrospective cohort study, we identified 279,085 offspring aged≥40 years between April 1, 1997 and December 31, 2015 with successful linkage to 273,852 mothers and 254,622 fathers. Parental cardiorespiratory conditions, including cerebral vascular disease, congestive heart failure, hypertension, ischemic heart disease, myocardial infarction, chronic obstructive pulmonary disease (COPD) and peripheral vascular disease, were ascertained using physician and hospital records dating back to 1979. The outcome was offspring incident major osteoporotic fracture (MOF).
Results:
During an average of 11.8 years of offspring follow-up, we identified 8762 (3.1%) incident MOF. Either parent congestive heart failure (adjusted hazard ratio [HR]: 1.13; 95% confidence interval [CI] 1.07-1.19) and COPD (adjusted HR: 1.12; 95% CI 1.07-1.17) were independently associated with increased offspring MOF risk; all their false discovery rates were <0.001. Similar risk estimates were observed when analyses were performed for fathers only, mothers only or both parents, in multivariable models with and without adjustment for offspring cardiorespiratory conditions, and stratified by offspring sex and offspring incident fracture site. Parental cerebrovascular disease, hypertension, ischemic heart disease and myocardial infarction were not associated with offspring MOF.
Conclusions:
Parental congestive heart failure and parental COPD are independent risk factors for offspring MOF.
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