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Published on: May 29, 2017
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Implant-forming polymeric 19F MRI-tracer with tunable dissolution
Kristyna Kolouchova1, Daniel Jirak2, Ondrej Groborz3
1Institute of Macromolecular Chemistry CAS, Heyrovsky Square 2, 162 06 Prague 6, Czech Republic; Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 8, Prague 2 128 00, Czech Republic.
Summary
Researchers developed novel injectable polymers for 19F MRI. These double-stimuli-responsive materials form implants that dissolve over time, offering a new tool for noninvasive diagnostics and monitoring.
Area of Science:
- Biomaterials Science
- Medical Imaging
- Polymer Chemistry
Background:
- 19F Magnetic Resonance Imaging (MRI) is a promising noninvasive diagnostic tool.
- Its application relies on diverse 19F-based tracers.
- Injectable implants require controlled dissolution and biocompatibility.
Purpose of the Study:
- To develop novel double-stimuli-responsive polymers for injectable implants.
- To enable controlled dissolution of implants with varying rates (30-250 days).
- To utilize 19F MRI for monitoring implant location and dissolution.
Main Methods:
- Synthesis of double-stimuli-responsive polymers with high fluorine content.
- Formation of injectable implants under physiological conditions.
- In vitro and in vivo biocompatibility and toxicity assessments.
- 19F MRI for implant monitoring in a rat model.
Main Results:
- Polymers formed stable implants that dissolved at controlled rates.
- 19F MRI successfully monitored implant location and dissolution.
- Materials exhibited excellent biocompatibility with no observed toxicity in vitro or in vivo.
- Demonstrated clinical applicability using a clinically relevant MRI instrument.
Conclusions:
- Developed injectable, stimuli-responsive polymers for 19F MRI applications.
- These polymers offer tunable dissolution kinetics and excellent biocompatibility.
- The technology shows significant potential for noninvasive diagnostic imaging and monitoring.
Keywords:
(19)F magnetic resonance imagingDouble-stimuli responsivityPolymer implantTunable dissolution
