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Updated: Aug 14, 2026

Induction of Experimental Autoimmune Hypophysitis in SJL Mice
Published on: December 17, 2010
Immunoglobulin G4-related hypertrophic pachymeningitis with spinal cord compression: A case report
Hong-Xing Li1, Lin Zuo1, Xiao-Xiao Peng2
1Department of Neurosurgery, Shengli Oilfield Central Hospital, 31 Jinan Road, Dongying, Shandong 257000, China.
Abstract:
IgG4-related disease (IgG4-RD) is a recently recognized inflammatory condition that can be found in many organs. However, spinal involvement is rare and has been described only in case reports and series. Here, we report a rare case of spinal IgG4-RD that resulted in hypertrophic pachymeningitis with spinal cord compression. This case expands the phenotypic presentation for the neurological sequelae of IgG4-RD. Our case hints that spinal IgG4-RD may be misdiagnosed, and IgG4-RD in patients should be considered when the patient has a dural mass. Although early surgery, steroids, and/or immunosuppressive therapy may prevent neurological complications, the side effects should receive more attention during treatment.
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