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Updated: Dec 13, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
New V1a receptor antagonist. Part 2. Identification and optimization of triazolobenzazepines
Éva Bozó1, Ferenc Baska1, Klára Lövei1
1Gedeon Richter Plc, Budapest 10, PO Box 27, H-1475, Hungary.
Abstract:
Solid preclinical evidence links vasopressin to social behavior in animals, so, extensive work has been initiated to find new vasopressin V1a receptor antagonists which can improve deteriorated social behavior in humans and can treat the core symptoms of autistic behavior, as well. Our aim was to identify new chemical entities with antagonizing effects on vasopressin V1a receptors. Continuing our previous work, we found an in vitro and in vivo orally active V1a selective antagonist molecule (40) among [1,2,4]triazolo[4,3-a][1]benzazepines.
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