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The Role of CDKs and CDKIs in Murine Development

Grace Jean Campbell1, Emma Langdale Hands1, Mathew Van de Pette1

  • 1Epigenetic Mechanisms of Toxicology Lab, MRC Toxicology Unit, Cambridge University, Cambridge CB2 1QR, UK.

International Journal of Molecular Sciences
|August 1, 2020
PubMed

Insights

Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) are crucial for embryonic development, regulating cell cycles and cell fate. Mouse models reveal their diverse roles, particularly in brain, pancreas, and fertility.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) and their inhibitors (CDKIs) are key regulators of the cell cycle.
  • Their essential roles in embryonic development are increasingly recognized.
  • While many CDKs and CDKIs exist in mice, few have been confirmed as essential for embryonic development.

Purpose of the Study:

  • To review mouse models studying CDK and CDKI functions in embryonic development.
  • To discuss the diverse roles of CDKs and CDKIs beyond cell cycle regulation.
  • To highlight their specific functions in the developing brain, pancreas, and fertility.

Main Methods:

  • Review of existing literature on mouse models for CDK and CDKI studies.
  • Analysis of data from genetic studies on CDKs and CDKIs in murine development.
  • Synthesis of findings on cell cycle regulation and cell fate determination.

Main Results:

  • A limited number of CDKs and a single CDKI are essential for murine embryonic development.
  • Many CDKs and CDKIs influence specific cell fates and tissue differentiation.
  • CDKs and CDKIs play critical roles in the development of the brain, pancreas, and reproductive systems.

Conclusions:

  • CDKs and CDKIs are vital for embryonic development, impacting both cell cycle control and cell differentiation.
  • Mouse models are instrumental in elucidating the complex functions of these proteins.
  • Further research into CDKs and CDKIs will enhance understanding of developmental processes and potential therapeutic targets.
Keywords:
CDK inhibitorscyclin-dependent kinasedevelopmentknock-out modelsmouse

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