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Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Enhancing Tumor Content through Tumor Macrodissection
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Inflammatory Cells in Diffuse Large B Cell Lymphoma.

Roberto Tamma1, Girolamo Ranieri2, Giuseppe Ingravallo3

  • 1Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, 70124 Bari, Italy.

Journal of Clinical Medicine
|August 1, 2020
PubMed
Summary
This summary is machine-generated.

Diffuse large B cell lymphoma (DLBCL) involves complex immune cell interactions within the tumor microenvironment. Targeting these immune cells offers new therapeutic strategies for treating this common non-Hodgkin lymphoma (NHL).

Keywords:
DLBCLNK cellsT cellsdendritic cellsmacrophagesneutrophilstumor cellstumor microenvironment

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Area of Science:

  • Oncology
  • Immunology
  • Hematology

Background:

  • Diffuse large B cell lymphoma (DLBCL) is the most prevalent subtype of non-Hodgkin lymphoma (NHL), exhibiting significant clinical and biological diversity.
  • The tumor microenvironment (TME) critically influences DLBCL initiation, progression, metastasis, and response to therapy.
  • Immune cell roles in DLBCL are multifaceted, involving intricate crosstalk between tumor cells, immune components, and the TME.

Purpose of the Study:

  • To review the complex roles of various immune cells within the DLBCL tumor microenvironment.
  • To explore the implications of these immune cells as potential therapeutic targets for DLBCL treatment.
  • To highlight novel immunotherapeutic strategies for enhancing anti-tumor immunity in DLBCL.

Main Methods:

  • Literature review focusing on the immunological landscape of DLBCL.
  • Analysis of the functions of macrophages, neutrophils, T cells, natural killer cells, and dendritic cells in the DLBCL TME.
  • Examination of emerging immunotherapeutic approaches targeting immune cells in DLBCL.

Main Results:

  • Specific immune cell populations within the DLBCL TME exert distinct influences on tumor progression and therapeutic outcomes.
  • Immune cells, including macrophages, neutrophils, T cells, NK cells, and dendritic cells, are key players in the DLBCL microenvironment.
  • Targeting these immune cells presents promising avenues for novel DLBCL treatments.

Conclusions:

  • Understanding the immune cell dynamics in the DLBCL TME is crucial for developing effective therapies.
  • Immuno-oncology strategies, such as vaccination or adoptive immunotherapy, can enhance the immune system's ability to combat DLBCL.
  • Targeting immune components offers a promising strategy to improve treatment efficacy and patient outcomes in DLBCL.