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Patient Management in Aortic Stenosis: Towards Precision Medicine Through Protein Analysis, Imaging and Diagnostic

Laura Mourino-Alvarez1, Tatiana Martin-Rojas1, Cecilia Corros-Vicente2,3

  • 1Department of Vascular Physiopathology, Hospital Nacional de Paraplejicos (HNP), SESCAM, 45071 Toledo, Spain.

Journal of Clinical Medicine
|August 1, 2020
PubMed

Insights

Aortic stenosis, a common heart valve disease, lacks early symptoms. This review explores promising protein markers and precision medicine for earlier detection and treatment of this growing health challenge.

Area of Science:

  • Cardiology
  • Biomarkers
  • Translational Medicine

Background:

  • Aortic stenosis is the most common valvular heart disease in developed nations.
  • It is characterized by progressive leaflet calcification, often presenting with nonspecific symptoms late in its course.
  • The increasing elderly population and patient comorbidities present significant management challenges.

Purpose of the Study:

  • To review key findings and translational studies on protein markers for aortic stenosis.
  • To discuss the potential role of precision medicine in managing aortic stenosis.
  • To identify indicators for early diagnosis, prognosis, and therapy.

Main Methods:

  • Comprehensive literature review of observational and translational studies.
  • Analysis of research on protein markers associated with aortic stenosis.
  • Discussion of precision medicine applications in the context of aortic stenosis.

Main Results:

  • Several protein markers show promise for clinical implementation in diagnosing and managing aortic stenosis.
  • Early detection of aortic stenosis remains a significant unmet need.
  • Precision medicine approaches may offer tailored therapeutic strategies.

Conclusions:

  • Identifying reliable diagnostic, prognostic, and therapeutic indicators is crucial for early aortic stenosis detection.
  • Protein markers and precision medicine represent key areas for future clinical advancements in aortic stenosis care.

Keywords:
aortic stenosisaortic valvebiomarkersprecision medicineproteomics

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