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Current Trends in ATRA Delivery for Cancer Therapy

Maria Valeria Giuli1, Patrizia Nadia Hanieh2, Eugenia Giuliani1

  • 1Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Pharmaceutics
|August 1, 2020
PubMed

Insights

All-Trans Retinoic Acid (ATRA) shows anti-tumor potential, but resistance and poor delivery limit its use in solid tumors. This review explores novel drug delivery systems to enhance ATRA

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • All-Trans Retinoic Acid (ATRA), a vitamin A metabolite, regulates cell differentiation and apoptosis.
  • ATRA exhibits anti-tumor activity, notably in Acute Promyelocytic Leukemia (APL) and Neuroblastoma (NB).
  • Clinical translation of ATRA for solid tumors is hindered by drug resistance and ineffective delivery.

Purpose of the Study:

  • To review recent advancements in ATRA-loaded Drug Delivery Systems (DDSs).
  • To analyze the efficacy of these DDSs in various tumor models.
  • To provide an overview of patents, preclinical, and clinical studies on ATRA delivery for cancer treatment.

Main Methods:

  • Comprehensive literature review of studies on ATRA-loaded DDSs.
  • Analysis of research focusing on overcoming ATRA resistance and improving targeting.
  • Inclusion of patent landscape, preclinical data, and clinical trial information.

Main Results:

  • Development of diverse DDSs aims to enhance ATRA's therapeutic index.
  • Promising results observed in preclinical tumor models utilizing novel ATRA delivery strategies.
  • Ongoing research and clinical investigations explore the potential of these DDSs.

Conclusions:

  • Novel DDSs offer a promising strategy to overcome ATRA resistance in solid tumors.
  • Improved delivery and targeting of ATRA are crucial for its broader clinical application in oncology.
  • Further research and clinical validation are essential to translate these findings into effective cancer therapies.
Keywords:
ATRADDSscancerdeliverytargeting

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