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Related Experiment Video

Updated: Dec 13, 2025

Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
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Indirect Structural Connectivity Identifies Changes in Brain Networks After Stroke.

Miguel R Sotelo1, Benjamin T Kalinosky1, Karin Goodfriend2

  • 1Department of Biomedical Engineering, Marquette University and the Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Brain Connectivity
|August 1, 2020
PubMed
Summary

Stroke impacts indirect brain connectivity, particularly in the cerebellum and fronto-parietal regions, correlating with motor impairment. These findings highlight indirect connectivity

Keywords:
diffusion imagingindirect connectivitystrokestructural connectivitytractographywhole brain

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Last Updated: Dec 13, 2025

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Rehabilitation Science

Background:

  • Stroke significantly disrupts brain networks, affecting both direct and indirect structural connectivity.
  • Understanding these network changes is crucial for predicting and managing post-stroke motor deficits.

Purpose of the Study:

  • To identify alterations in structural connectivity following stroke.
  • To correlate changes in indirect connectivity with the severity of post-stroke motor impairment.

Main Methods:

  • Employed a novel measure of indirect connectivity alongside probabilistic tractography in chronic stroke survivors and controls.
  • Assessed motor impairment using the Fugl-Meyer assessment.
  • Calculated network measures of direct and indirect connectivity, combined with white matter integrity, to predict motor impairment.

Main Results:

  • Found significantly reduced indirect connectivity in frontal and parietal lobes, ipsilesional subcortical regions, and the cerebellum post-stroke.
  • The volume of gray matter with reduced indirect connectivity significantly improved the prediction of upper extremity motor impairment (R² = 0.71, p < 0.05).

Conclusions:

  • Stroke causes changes in indirect connectivity in regions remote from the lesion, notably the cerebellum and fronto-parietal cortices.
  • These indirect connectivity changes correlate with upper extremity motor impairment, suggesting their importance in recovery.
  • Measures of indirect connectivity may enhance prognostication of stroke outcomes.