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Updated: Dec 13, 2025

Imaging of the Microstructural Failure Mechanism in the Human Hip
Published on: September 29, 2023
Combined two-centre experience of single-entry telescopic rods identifies characteristic modes of failure
India Cox1, Louay Al Mouazzen1, Sabri Bleibleh2
1Bristol Royal Hospital for Children, Bristol, UK.
Insights
The Fassier Duval (FD) rod for osteogenesis imperfecta (OI) shows high revision rates, similar to older implants. Fixation issues in the femur and tibia are common, especially in younger children, necessitating future implant improvements.
Area of Science:
- Pediatric Orthopedics
- Biomaterials Science
- Skeletal Dysplasias
Background:
- Osteogenesis imperfecta (OI) is a genetic disorder characterized by brittle bones.
- Telescopic intramedullary rods are used to stabilize long bones in children with severe OI.
- The Fassier Duval (FD) rod is a third-generation implant designed for easier insertion.
Purpose of the Study:
- To evaluate the clinical outcomes and implant survival of the Fassier Duval (FD) rod in children with severe osteogenesis imperfecta (OI).
- To identify complications and failure modes associated with FD rod implantation.
- To compare the performance of FD rods with previous generations of telescopic implants.
Main Methods:
- A retrospective review of 34 children with severe OI treated with FD rods in 72 lower limb long bones.
- Prospective data collection with a follow-up period of 1.5 to 11 years.
- Analysis of implant survival rates, revision rates, and specific complications such as rod bending, refractures, and fixation failures.
Main Results:
- A 33% revision rate was observed, with 11 rods bending and causing refractures.
- Proximal femoral and distal tibial fixation failures were common.
- The five-year survival rate for femoral rods was 63% and for tibial rods was 64%.
Conclusions:
- FD rods offer easier implantation but do not surpass the revision rates of second-generation implants.
- Proximal femoral fixation is problematic in younger children, and distal tibial fixation failures occur frequently.
- Future implant designs must address fixation challenges in the proximal femur and distal tibia to reduce complications in OI patients.
Aims:
The Fassier Duval (FD) rod is a third-generation telescopic implant for children with osteogenesis imperfecta (OI). Threaded fixation enables proximal insertion without opening the knee or ankle joint. We have reviewed our combined two-centre experience with this implant.
Methods:
In total, 34 children with a mean age of five years (1 to 14) with severe OI have undergone rodding of 72 lower limb long bones (27 tibial, 45 femoral) for recurrent fractures with progressive deformity despite optimized bone health and bisphosphonate therapy. Data were collected prospectively, with 1.5 to 11 years follow-up.
Results:
A total of 24 patients (33%) required exchange of implants (14 femora and ten tibiae) including 11 rods bending with refracture. Four (5%) required reoperation with implant retention. Loss of proximal fixation in the femur and distal fixation in the tibia were common. Four patients developed coxa vara requiring surgical correction. In total, 13 patients experienced further fractures without rod bending; eight required implant revision. There was one deep infection. The five-year survival rate, with rod revision as the endpoint, was 63% (95% confidence interval (CI) 44% to 77%) for femoral rods, with a mean age at implantation of 4.8 years (1.3 to 14.8), and 64% (95% CI 36% to 82%) for tibial rods, with a mean age at implantation of 5.2 years (2.0 to 13.8).
Conclusion:
FD rods are easier to implant but do not improve on the revision rates reported for second generation T-piece rods. Proximal femoral fixation is problematic in younger children with a partially ossified greater trochanter. Distal tibial fixation typically fails after two years. Future generation implants should address proximal femoral and distal tibial fixation to avoid the majority of complications in this series. Cite this article: Bone Joint J 2020;102-B(8):1048-1055.
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