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Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress.

Aviru Kumar Basu¹, Adreeja Basu², Shantanu Bhattacharya³

¹Design Programme, Indian Institute of Technology, Kanpur, U.P. 208016, India; Microsystems Fabrication Laboratory, Department of Mechanical Engineering, Indian Institute of Technology, Kanpur, U.P. 208016, India; Singapore University of Technology and Design, 487372 Singapore.

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Summary

Miniaturized bioanalytical devices using micro/nano cantilevers offer sensitive, label-free detection. This review covers their principles, methods, and advancements for portable biosensing applications.

Keywords:

Biosensing Cantilever MEMS Progress Surface functionalization

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Area of Science:

Biosensing
Nanotechnology
Analytical Chemistry

Background:

Miniaturized bioanalytical devices are crucial for portable, label-free detection.
Cantilever-based devices have significantly improved due to micro/nanofabrication and surface functionalization.
Scaling cantilevers to the nanoscale enhances sensitivity and introduces unique properties.

Purpose of the Study:

To review the fundamental principles of cantilever operation in biosensing.
To discuss various detection methods and historical, current, and future approaches.
To highlight major bio-sensing efforts and recent progress using micro/nano cantilevers.

Main Methods:

Review of scientific literature on cantilever-based biosensing.
Analysis of micro/nanofabrication and surface functionalization techniques.
Discussion of fundamental principles and detection methodologies.

Main Results:

Cantilever performance has advanced significantly with micro/nanofabrication.
Nanoscale cantilevers exhibit exceptional sensitivity and anomalous properties.
The field has seen substantial progress in bio-sensing applications.

Conclusions:

Cantilever-based platforms are key for sensitive, portable biosensing.
Continued advancements in fabrication and functionalization drive performance.
The review provides a comprehensive overview of past, present, and future directions.