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Updated: Dec 13, 2025
07:10
Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
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What we talk about when we talk about durable viral suppression.
Karen Diepstra1, Haidong Lu1, Kathleen A McManus2
1Department of Epidemiology, UNC-Chapel Hill, Chapel Hill, North Carolina.
AIDS (London, England)
|August 1, 2020
Summary
Durable viral suppression (DVS) is increasingly used in HIV research. However, many studies lack a clear definition for DVS, hindering comparability and public health progress.
Area of Science:
- Public Health
- Infectious Diseases
- Epidemiology
Background:
- The 'Undetectable = Untransmittable' (U=U) policy promotes durable viral suppression (DVS) in HIV management.
- DVS is increasingly utilized as a key outcome in HIV research analyses.
Purpose of the Study:
- To review recent HIV publications focusing on DVS as an outcome.
- To assess the clarity and consistency in defining and operationalizing DVS in current research.
Main Methods:
- A case series approach was used to identify and analyze recent HIV-related publications.
- The analysis focused on how Durable Viral Suppression (DVS) was defined and operationalized within these studies.
Main Results:
- The majority of reviewed studies failed to differentiate between the conceptual definition of DVS and its practical application.
- Inconsistency in DVS definitions and operationalization was prevalent across the analyzed literature.
Conclusions:
- A formal and clear definition of Durable Viral Suppression (DVS) is necessary for HIV research.
- Standardizing DVS definitions will improve study comparability and enhance public health outcomes in HIV prevention and treatment efforts.
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