Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

119
Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
119
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

226
Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
226
Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

590
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
590
Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

82
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
82
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

311
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
311
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

102
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ivonescimab: The Next United States Food and Drug Administration Project Optimus Flashpoint?

JTO clinical and research reports·2026
Same author

Heterogeneous survival impact of immune-related adverse events in US veterans.

Journal for immunotherapy of cancer·2026
Same author

Maintenance Pemetrexed/Pembrolizumab Versus Pembrolizumab in Non-Small Cell Lung Cancer: A Propensity Score-Weighted Analysis.

JCO oncology practice·2026
Same author

Morning versus afternoon administration of immune checkpoint inhibitors in metastatic non-small-cell lung cancer.

Journal for immunotherapy of cancer·2026
Same author

Comparative and Critical Analysis of Immune-based Combinations for First-line Treatment of Metastatic Renal Cell Carcinoma.

Clinical genitourinary cancer·2026
Same author

When the world turned upside down: A Veterans Affairs PTSD specialty clinic in the COVID-19 era.

Psychological services·2026

Related Experiment Video

Updated: Dec 13, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.7K

Interventional Pharmacoeconomics.

Daniel A Goldstein, Garth W Strohbehn, Anthony V Serritella1

  • 1Section of Hematology/Oncology, University of Chicago Medicine, Chicago, IL.

Cancer Journal (Sudbury, Mass.)
|August 1, 2020
PubMed
Summary
This summary is machine-generated.

Rising oncology drug costs challenge healthcare. Developing lower-cost, off-label treatments using pharmacologic rationale offers an economically impactful alternative solution.

More Related Videos

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.7K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.9K

Related Experiment Videos

Last Updated: Dec 13, 2025

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

8.7K
Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology
10:46

Non-fluoroscopic Catheter Tracking for Fluoroscopy Reduction in Interventional Electrophysiology

Published on: May 26, 2015

13.7K
Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study
09:18

Intraventricular Drug Delivery and Sampling for Pharmacokinetics and Pharmacodynamics Study

Published on: March 31, 2022

2.9K

Area of Science:

  • Health Economics
  • Oncology
  • Pharmacology

Background:

  • Increasing healthcare costs pose a global challenge, particularly in the United States.
  • The escalating price of oncology drugs significantly contributes to rising healthcare expenditures.
  • Current solutions often focus on broad health policy changes.

Purpose of the Study:

  • To introduce and describe the approach of interventional pharmacoeconomics.
  • To present off-label treatment regimens as a viable strategy for reducing oncology drug costs.
  • To highlight the economic impact of pharmacologically-guided treatment selection.

Main Methods:

  • Identifying drugs with suitable pharmacologic and clinical properties for alternative uses.
  • Developing evidence-based, lower-cost off-label treatment regimens.
  • Analyzing the potential economic impact of these alternative regimens.

Main Results:

  • Demonstrated the feasibility of using existing drugs in novel, cost-effective ways.
  • Provided multiple examples of successful interventional pharmacoeconomics strategies.
  • Highlighted significant potential for cost savings in cancer care.

Conclusions:

  • Interventional pharmacoeconomics offers a practical alternative to traditional health policy changes for managing drug costs.
  • Off-label treatment strategies, when based on sound pharmacologic principles, can lead to substantial economic benefits.
  • This approach has the potential to improve the affordability of cancer care.