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Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

Lymphoid Cells and Tissues

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...

Detailed Structure and Function of Lymph Nodes

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...

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Related Experiment Video

Updated: Dec 13, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Marginal Zone Lymphomas.

Francesco Bertoni, Davide Rossi, Markus Raderer¹

¹Internal Medicine I, Oncology, Medical University of Vienna, Vienna, Austria.

Cancer Journal (Sudbury, Mass.)

|August 1, 2020

Summary

This summary is machine-generated.

Marginal zone lymphomas (MZLs) are categorized into three types with shared genetic alterations and differing mutations. This review details advances in MZL genetics, biology, and novel therapeutic strategies.

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Last Updated: Dec 13, 2025

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Published on: September 12, 2025

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Analysis of Shear Flow-induced Migration of Murine Marginal Zone B Cells In Vitro

Published on: November 26, 2018

Area of Science:

Hematology
Oncology
Genetics

Background:

Marginal zone lymphomas (MZLs) encompass three distinct entities: extranodal MZL of mucosa-associated lymphoid tissue, splenic MZL, and nodal MZL.
These subtypes share common genetic lesions, including trisomies of chromosomes 3 and 18, and 6q23 deletions.
Frequent alterations in the nuclear factor κB pathway are observed across all MZL types.

Purpose of the Study:

To review recent advancements in understanding the genetics and biology of marginal zone lymphomas.
To summarize the clinical efficacy of novel therapeutic approaches targeting key pathways in MZLs.
To discuss current management principles for MZLs at various anatomical sites.

Main Methods:

Literature review of recent studies on MZL genetics and biology.
Analysis of clinical trial data for novel therapeutic agents targeting MZL pathways.
Synthesis of current clinical guidelines for MZL management.

Main Results:

MZLs exhibit common genetic hallmarks and pathway alterations, alongside distinct genetic events such as specific translocations and mutations (e.g., NOTCH pathway, KLF2, PTPRD).
Novel therapeutic strategies targeting key molecular pathways show promising clinical activity.
Standard management protocols vary based on the anatomical site of MZL.

Conclusions:

Understanding the distinct genetic landscapes and shared pathways of MZLs is crucial for targeted therapy development.
Emerging therapies offer new hope for patients with marginal zone lymphomas.
A comprehensive approach integrating genetic insights and clinical management is essential for optimal patient outcomes.