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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Long Intergenic Non-protein Coding RNA 511 in Cancers.

Xiao-Fei Wang1, Bo Liang2, Cheng Chen1

  • 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

Frontiers in Genetics
|August 1, 2020
PubMed
Summary

Long intergenic non-protein coding RNA 511 (LINC00511) is linked to poorer overall survival (OS) and increased lymph node metastasis in various cancers. This suggests LINC00511 is an unfavorable prognostic factor in oncology.

Keywords:
LINC00511bioinformaticscancermeta-analysisprognostic biomarkersurvival

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Long intergenic non-protein coding RNA 511 (LINC00511) is frequently upregulated in numerous cancers.
  • Its role in cancer prognosis requires comprehensive evaluation.

Approach:

  • A meta-analysis synthesized data from 9 published studies on LINC00511 and cancer prognosis.
  • Validation and functional analyses were performed using GEPIA and LnCeVar databases.
  • Clinicopathological correlations and genomic variations were investigated.

Key Points:

  • LINC00511 upregulation significantly correlates with decreased overall survival (OS) across multiple cancer types, including breast, digestive, and cervical cancers.
  • The expression of LINC00511 is associated with age, clinical stage, tumor size, and lymph node metastasis.
  • Functional enrichment analysis revealed LINC00511's involvement in cancer-related pathways and ceRNA networks.

Conclusions:

  • LINC00511 serves as a potential unfavorable prognostic biomarker for overall survival and lymph node metastasis in various cancers.
  • The mechanism underlying LINC00511's prognostic role involves the competing endogenous RNA (ceRNA) network.