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Updated: Dec 13, 2025

Cerebral Blood Oxygenation Measurement Based on Oxygen-dependent Quenching of Phosphorescence
Published on: May 4, 2011
Nonstationary Model of Oxygen Transport in Brain Tissue
Andrey E Kovtanyuk1,2, Alexander Yu Chebotarev2,3, Nikolai D Botkin4
1Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 München, Germany.
Abstract:
The paper addresses the mathematical study of a nonstationary continuum model describing oxygen propagation in cerebral substance. The model allows to estimate the rate of oxygen saturation and stabilization of oxygen concentration in relatively large parts of cerebral tissue. A theoretical and numerical analysis of the model is performed. The unique solvability of the underlying initial-boundary value problem for a system of coupled nonlinear parabolic equations is proved. In the numerical experiment, the tissue oxygen saturation after hypoxia is analyzed for the case when a sufficient amount of oxygen begins to flow into the capillary network. A fast stabilization of the tissue oxygen concentration is demonstrated. The reliability of the results of the numerical simulation is discussed.
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