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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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CHA2DS2-VASc Score as a Predictor for Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular

Ping Sun1, Zhi Hao Guo1, Hong Bin Zhang1

  • 1Vasculocardiology Deparment, Cangzhou Central Hospital, No. 16 Xinhua Road, Yunhe Qu, Cangzhou 061000, China.

Biomed Research International
|August 1, 2020
PubMed

Insights

The CHA₂DS₂-VASc score predicts left atrial thrombus (LAT) and spontaneous echo contrast (LASEC) in nonvalvular atrial fibrillation (NVAF) patients. This meta-analysis confirms the score

Area of Science:

  • Cardiology
  • Medical Diagnostics
  • Clinical Research

Background:

  • Nonvalvular atrial fibrillation (NVAF) increases stroke risk.
  • Left atrial thrombus (LAT) and spontaneous echo contrast (LASEC) are key indicators of thromboembolic events in NVAF patients.
  • Predictive tools for LAT/LASEC are crucial for risk stratification in NVAF.

Purpose of the Study:

  • To evaluate the predictive capability of the CHA₂DS₂-VASc score for the presence of LAT or LASEC in patients with NVAF.
  • To synthesize existing evidence through a comprehensive meta-analysis.

Main Methods:

  • Systematic literature search across major databases (PubMed, Embase, Web of Science, etc.) up to January 2020.
  • Inclusion of 15 studies encompassing 6223 NVAF patients.
  • Pooled odds ratios (ORs) calculated using random-effects models, with heterogeneity, subgroup, publication bias, and sensitivity analyses performed.

Main Results:

  • A high CHA₂DS₂-VASc score was significantly associated with both LAT/LASEC (pooled OR = 1.59) and LAT alone (pooled OR = 1.83).
  • High heterogeneity was observed (I² > 75%), with subgroup analysis suggesting sample size as a potential source.
  • Publication bias was detected, but sensitivity analyses confirmed the robustness of the pooled findings.

Conclusions:

  • The CHA₂DS₂-VASc score demonstrates a significant association with LAT and LASEC in NVAF patients.
  • While the score is a valuable predictor, further research is recommended to refine its predictive accuracy and address heterogeneity.
Abstract

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