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Related Experiment Videos

Vascular changes in cutaneous neurofibromas.

F Teixeira1, A Martinez-Palomo, V M Riccardi

  • 1Section of Experimental Pathology, National Polytechnic Institute, Mexico City, Mexico.

Neurofibromatosis
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Neurofibromas exhibit unique microvascular changes, including thickened endothelial cells and abundant pericytes. These alterations suggest a developmental vascular malformation rather than tumor-induced angiogenesis.

Area of Science:

  • Vascular Biology
  • Dermatopathology
  • Genetics

Background:

  • Neurofibromatosis is associated with vascular abnormalities.
  • Previous research focused on arterial changes, neglecting neurofibroma microvasculature.

Purpose of the Study:

  • To investigate the structural modifications of microvessels within cutaneous neurofibromas.
  • To compare these microvessels to normal skin vessels.

Main Methods:

  • Transmission electron microscopy was used.
  • Small vessels from 10 neurofibroma samples were analyzed.
  • Samples were compared to normal skin vessels.

Main Results:

  • Endothelial cells showed thickened cytoplasm and lumen-obliterating processes.

Related Experiment Videos

  • Increased abluminal endothelial cell processes interacted with pericyte processes.
  • Endothelial cells had more cytoplasmic filaments and ribosomes.
  • Pericytes were abundant, featuring cytoplasmic filaments and subplasmalemmal densities.
  • No mitotic figures were observed in vascular elements.

    • Conclusions:

    • The observed vascular changes in neurofibromas are likely due to a generalized malformative process.
    • These alterations are not attributed to tumor angiogenesis factors.