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Hydroxychloroquine Alternatives for Chronic Disease: Response to a Growing Shortage Amid the Global COVID-19 Pandemic

Sameeha S Husayn1, Jeremy D Brown1, Colby L Presley1

  • 1College of Osteopathic Medicine, Rocky Vista University, Parker, CO, USA.

Journal of Pharmacy Practice
|August 1, 2020
PubMed

Insights

Hydroxychloroquine (HCQ) is being investigated for COVID-19 treatment, raising ethical concerns. Pharmacists play a crucial role in managing HCQ for both COVID-19 and chronic conditions, ensuring equitable access and patient education.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Medical Ethics

Background:

  • The emergence of a novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has prompted global research into treatments, diagnostics, and vaccines.
  • Effective treatments for coronavirus disease 2019 (COVID-19) remain largely elusive.
  • Chloroquine phosphate and hydroxychloroquine sulfate (HCQ) are antimalarial drugs with existing therapeutic uses, now under investigation for COVID-19.

Purpose of the Study:

  • To review the use of hydroxychloroquine (HCQ) in the context of the COVID-19 pandemic.
  • To discuss the ethical considerations surrounding the increased use and demand for HCQ.
  • To highlight the role of pharmacists in managing HCQ for both COVID-19 and chronic conditions.

Main Methods:

  • Literature review of HCQ use for COVID-19 and chronic conditions.
  • Analysis of ethical considerations including patient autonomy and distributive justice.
  • Discussion of the pharmacist's role in drug management and patient education.

Main Results:

  • The United States Food and Drug Administration issued an Emergency Use Authorization for HCQ in COVID-19 treatment.
  • Increased demand for HCQ has led to significant ethical challenges regarding its appropriate use and distribution.
  • Pharmacists are essential in advocating for patients, ensuring appropriate prescribing, and educating stakeholders.

Conclusions:

  • Pharmacists are uniquely positioned to navigate the complexities of HCQ use during the COVID-19 crisis.
  • Ensuring equitable distribution of HCQ for both COVID-19 patients and those with chronic conditions is a key responsibility.
  • Continuous education for patients and healthcare professionals is vital throughout this public health emergency.
Keywords:
coronavirus disease 2019distributive justicehydroxychloroquinenonmaleficence

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