Morphological changes in the lower limbs with the progression of knee osteoarthritis over 6 years in a Toei cohort
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Updated: Dec 13, 2025

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
Dung Huu Tran1, Hironobu Hoshino1, Yukihiro Matsuyama1
1Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
Objectives:
We investigated the relationship between morphological features in the lower limbs and the progression of knee osteoarthritis (OA) in 6-years.
Methods:
Volunteer subjects from Toei (101 women and 54 men). Knee OA was evaluated on whole-leg radiographs. Subjects were divided into group 1, no knee OA; group 2, stable knee OA that showed no progression; group 3, knee OA that had progressed over 6 years. Demographic hip and knee measurement factors were compared the three groups.
Results:
Women, age, body mass index (BMI), abductor angle of the hip, and mechanical-axis deviation were higher in group 2 than in group 1. BMI, the mechanical axis deviation were higher in group 3 than in group 1. Femoral offset was lower in group 3 than in groups 1 and 2. Men, age, condylar-hip angle, plateau-ankle angle were higher in group 2 than in group 1. Age, BMI were higher in group 3 than in groups 1. Condylar-hip and plateau-ankle angles were lower in group 3 than in group 2.
Conclusions:
Strategies aimed at strengthening the muscles around the hip, changes in lifestyle should be implemented, especially in patients with changes in geometric indices of the hip and knee.
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