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Updated: Dec 13, 2025

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Prevention of contrast-induced acute kidney injury in patients undergoing percutaneous coronary intervention
Marco Legnazzi1, Federica Agnello1, Davide Capodanno2
1Division of Cardiology, A.O.U. Policlinico “G. Rodolico‑San Marco,” University of Catania, Catania, Italy
Insights
Contrast media used in percutaneous coronary intervention can cause kidney injury. This review covers risk factors and prevention strategies for contrast-induced acute kidney injury (CI-AKI) in these patients.
Area of Science:
- Nephrology
- Cardiology
- Radiology
Background:
- Contrast media administration is essential for percutaneous coronary intervention (PCI).
- Contrast-induced acute kidney injury (CI-AKI) is a frequent complication of PCI, impacting patient prognosis.
- Patient comorbidities and procedural factors are significant risk factors for CI-AKI.
Purpose of the Study:
- To review current evidence on CI-AKI in patients undergoing PCI.
- To discuss risk factors associated with CI-AKI development.
- To explore future research directions for CI-AKI prevention.
Main Methods:
- Literature review of existing studies on CI-AKI and PCI.
- Analysis of identified risk factors for CI-AKI.
- Discussion of current and emerging prevention strategies.
Main Results:
- CI-AKI is a common and prognostically relevant complication of PCI.
- Specific patient comorbidities and procedural characteristics increase CI-AKI risk.
- Evidence-based prevention strategies are crucial for mitigating CI-AKI.
Conclusions:
- CI-AKI remains a significant concern in PCI procedures.
- Identifying and managing risk factors is key to CI-AKI prevention.
- Further research is needed to optimize CI-AKI prevention strategies in PCI patients.
Abstract:
Intravascular administration of contrast media is an irreplaceable step of percutaneous coronary intervention. Since the latter is a very common procedure, contrast‑induced acute kidney injury (CI‑AKI) has become one of the most frequent causes of acute nephropathy, and a relevant prognostic impact of CI‑AKI has been observed. Some patient comorbidities and procedural characteristics have been identified as key risk factors of CI‑AKI. In this review, we discuss current evidence and future research directions on CI‑AKI prevention in patients undergoing percutaneous coronary intervention.
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