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Updated: Dec 13, 2025

Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

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Published on: November 29, 2024

Diabetic Cardiomyopathy: From Mechanism to Management in a Nutshell.

Shahzad Khan¹, Syed S Ahmad², Mohammad A Kamal³

¹Department of Pathophysiology, Wuhan University School of Medicine, Hubei, Wuhan, China.

Endocrine, Metabolic & Immune Disorders Drug Targets

|August 1, 2020

Summary

Diabetic cardiomyopathy (DCM) involves heart dysfunction due to diabetes, causing fibrosis and impaired pumping. Understanding its complex causes aids in developing effective treatments for this serious heart condition.

Keywords:

Diabetic cardiomyopathy diabetes mellitus heart failure hyperglycemia insulin resistance pathophysiology

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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

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Published on: September 18, 2017

Area of Science:

Cardiology
Endocrinology
Pathophysiology

Background:

Diabetic cardiomyopathy (DCM) is a serious heart complication of diabetes mellitus.
It involves cardiac remodeling like fibrosis and dysfunction, unrelated to coronary artery disease.
Insulin resistance and hyperglycemia are key triggers for DCM initiation.

Purpose of the Study:

To briefly discuss the pathophysiology of diabetic cardiomyopathy.
To mention current therapeutic strategies for DCM.

Main Methods:

Review of existing literature on DCM pathophysiology.
Summary of current therapeutic approaches.

Main Results:

DCM involves multiple pathophysiological events including lipotoxicity, oxidative stress, inflammation, and RAAS activation.
These lead to cardiac cell injury, apoptosis, fibrosis, and impaired diastolic and systolic function.
Ultimately, these changes result in clinical heart failure.

Conclusions:

Diabetic cardiomyopathy is a complex condition driven by metabolic and inflammatory pathways.
Current understanding points to various therapeutic targets for managing DCM.