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Analysis of the Efficacy of Iloprost Treatment in Amputations Due to Burn

Fehim Can Sevil1, Hülya Sevil2, Mehmet Tort3

  • 1Department of Cardiovascular Surgery, Afyonkarahisar Health Sciences University Hospital, Turkey.

Journal of Burn Care & Research : Official Publication of the American Burn Association
|August 1, 2020
PubMed

Insights

Iloprost treatment significantly reduces amputation rates in burn patients with vascular injury. This study found a dramatic decrease in amputations among those receiving iloprost, highlighting its effectiveness.

Area of Science:

  • Medical Research
  • Burn Treatment
  • Vascular Surgery

Background:

  • Burn injuries frequently lead to vascular complications, increasing the risk of amputation.
  • Effective management of burn-related vascular injury is crucial to prevent limb loss.
  • Iloprost, a vasodilator, has shown potential in improving microcirculation.

Purpose of the Study:

  • To evaluate the efficacy of iloprost treatment in reducing amputation rates among burn patients.
  • To compare amputation incidence in burn patients with vascular injury, with and without iloprost.
  • To analyze the impact of iloprost on outcomes for patients experiencing burn-related vascular compromise.

Main Methods:

  • Retrospective analysis of 366 adult burn patients treated between 2016 and 2019.
  • Data collection included demographics, burn etiology, vascular findings, treatments, and amputation rates.
  • Comparison of amputation rates between patients treated with iloprost and those not receiving it.

Main Results:

  • Vascular injury occurred in 16.3% of burn patients, with higher incidence in electrical and cold burns.
  • Of 60 patients with vascular injury, 21 received iloprost treatment.
  • Amputation occurred in only one patient (4.8%) treated with iloprost, versus 19 patients (47.5%) not treated with iloprost (P < .001).

Conclusions:

  • Iloprost treatment is highly effective in reducing amputation rates in burn patients with vascular injury.
  • Early intervention with iloprost may prevent severe outcomes like amputation.
  • Iloprost represents a valuable therapeutic option for managing burn-related vascular complications.

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